Does Depression Increase the Risk of Endometriosis? A Combined Population‑Based and Laboratory Study
Yuru Wang, Zihan Zhu, Xu Jin, Zhaoyan Ding, Wen Zhong, Yueming Zhang, Songwei Feng, Ting Wu · 2026
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Description
Depression and endometriosis travel as a pair, and a 2026 study led by Yuru Wang asks which one drives the other. Combining gene studies with cell tests, the article tests which way cause runs between several mental conditions and the estrogen-driven pelvic disease using Mendelian randomization.
Genetic risk for depression raised endometriosis risk in the forward analysis, while anxiety, insomnia, bipolar illness, and schizophrenia showed no robust causal signal. The reverse check found no evidence that endometriosis risk causes mental illness in these data. In the lab, stress-system nerve cells let out more norepinephrine and sped growth of endometriotic cells, giving the genetic result a plausible living echo.
Catalog record
| CREATOR | Yuru Wang, Zihan Zhu, Xu Jin, Zhaoyan Ding, Wen Zhong, Yueming Zhang, Songwei Feng, Ting Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |