Methylene Blue for Prevention of Perioperative Neurocognitive Disorders: Mechanisms and Recent Clinical Evidence
Yu Wu, Jinbao Wang, Xiaojian Wan · 2026
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Description
An old blue dye might guard aging brains through surgery, and a 2026 review authored by Yu Wu builds the case for methylene blue. The article pulls together early and clinical evidence on perioperative neurocognitive disorders, which strike a large share of elderly patients after surgery and raise later dementia risk.
Proposed mechanisms converge on mitochondria: the dye can shuttle electrons, switch on antioxidant defenses, calm brain-cell inflammation, block tau clumping, and protect the blood-brain barrier. Small randomized trials report that one dose by vein during surgery cut delirium after surgery sharply in older patients having major non-cardiac surgery. The authors call for large trials at many centers to confirm dosing and benefit.
Catalog record
| CREATOR | Yu Wu, Jinbao Wang, Xiaojian Wan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |