Genome-Wide Association Study of Psoriasis, Psoriatic Arthritis, Anti–TNF-α Response, and Polygenic Risk Score in a Russian Cohort
Arfenya E. Karamova, Anastasiia A. Buianova, Anastasiia A. Vorontsova, Alexey A. Kubanov · 2026
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Description
Arfenya Karamova and co-authors scan the genomes of a Russian group for variants tied to psoriasis and its joint form, in work from twenty twenty-six. Psoriasis is an immune skin disease with a strong genetic part. The team also probed response to a class of targeted drugs.
The scan covered more than a thousand patients and more than nine thousand controls on gene chips. A known immune region near the HLA-C gene gave a very strong signal, as expected. Two other gene regions added fresh leads. Signals for drug response and joint disease were weak and marked as early leads only. A combined risk score gave modest prediction. The authors urge outside checks before any clinical use.
Catalog record
| CREATOR | Arfenya E. Karamova, Anastasiia A. Buianova, Anastasiia A. Vorontsova, Alexey A. Kubanov |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |