Dynamic Time-Resolved Remodeling of the Immune Microenvironment After Resistance to BRAF/MEK Inhibitors in Melanoma: Mechanisms, Biomarkers, and Emerging Therapeutic Strategies
Wenjun Meng, Yan Liu, Haoran Zhang, Manting Wang, Xiaoli Mu, Ziqi Zhang, Yan Tie · 2026
Read Dynamic Time-Resolved Remodeling of the Immune Microenvironment After Resistance to BRAF/MEK Inhibitors in Melanoma: Mechanisms, Biomarkers, and Emerging Therapeutic Strategies by Wenjun Meng, Yan Liu, Haoran Zhang, Manting Wang, Xiaoli Mu, Ziqi Zhang, Yan Tie (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13207537.txt.
Description
Wenjun Meng and co-authors review in 2026 how the immune landscape around a melanoma shifts as the tumor learns to resist targeted drugs. Two drugs that block a growth pathway shrink most such tumors fast, yet resistance almost always follows. The review's angle is time: resistance is not a single event but a moving remodeling of the tissue around the tumor.
Early in treatment, tumors often show more target markers and draw in more killer immune cells, opening a brief window where immune therapy might work best. Warning signs appear at the same time, including brakes on immune cells. At relapse, tumors hide their markers and shut immune cells out. The authors map markers to check at start, during treatment, and at relapse. They also weigh next-step options, from paired immune drugs to new combinations, and call for trials built around this timing.
Catalog record
| CREATOR | Wenjun Meng, Yan Liu, Haoran Zhang, Manting Wang, Xiaoli Mu, Ziqi Zhang, Yan Tie |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |