Integrated Network Pharmacology and Single-Cell Transcriptomics Reveal Transketolase as a Potential Target for the DanShen–DaHuang Herb Pair in Acute Kidney Injury
Yang Zhang, Haolan Yang, Jin Li, Xinyan Wu, Lixia Li, Gang Ye, Kun Zhang, Zhijun Zhong · 2026
Read Integrated Network Pharmacology and Single-Cell Transcriptomics Reveal Transketolase as a Potential Target for the DanShen–DaHuang Herb Pair in Acute Kidney Injury by Yang Zhang, Haolan Yang, Jin Li, Xinyan Wu, Lixia Li, Gang Ye, Kun Zhang, Zhijun Zhong (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13207515.txt.
Description
Yang Zhang and co-authors hunt drug targets for a Chinese herb pair in a 2026 study. The DanShen-DaHuang pair protects kidneys in lab models of acute injury, but its targets were unknown. The team crossed herb compound targets with disease gene networks, then ranked candidates with six machine learning methods and mapped them in single-cell data.
One enzyme, transketolase, ranked first. It concentrates in repair-type kidney macrophages and rises along their maturation path. Docking tests showed herb compounds fit its pocket well. Readers get a data-driven lead for how this herb pair may calm kidney injury.
Catalog record
| CREATOR | Yang Zhang, Haolan Yang, Jin Li, Xinyan Wu, Lixia Li, Gang Ye, Kun Zhang, Zhijun Zhong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |