Phosphonamidates Integrating Sterically Hindered Phenols with Membrane-Active Cations: A Redox-Activated Approach to Antimicrobial Agents
Elmira Gibadullina, Adel Shakirov, Margarita Neganova, Yulia Aleksandrova, Alexandra Voloshina, Anna Lyubina, Anastasiya Sapunova, Anna Strelnik, Kamil Ivshin, Assel Shuragaziyeva, Altynkul Toibazarova, Banu Diyarova, Anipa Tapalova, Nurbol Appazov, Alexander Burilov · 2026
Read Phosphonamidates Integrating Sterically Hindered Phenols with Membrane-Active Cations: A Redox-Activated Approach to Antimicrobial Agents by Elmira Gibadullina, Adel Shakirov, Margarita Neganova, Yulia Aleksandrova, Alexandra Voloshina, Anna Lyubina, Anastasiya Sapunova, Anna Strelnik, Kamil Ivshin, Assel Shuragaziyeva, Altynkul Toibazarova, Banu Diyarova, Anipa Tapalova, Nurbol Appazov, Alexander Burilov (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13207327.txt.
Description
Elmira Gibadullina and a large team of co-authors report a 2026 chemistry study on new agents against bacteria. The team joined three parts into single molecules. One part is charged and breaks bacterial membranes. A linker can switch the molecule on, and a shielded phenol part can drive redox chemistry.
The team made forty such hybrid compounds, most in high yield. Tests against major disease bacteria, including a drug-resistant staph strain, showed strong action against Gram-positive types. The best compounds stopped growth at doses up to ten times lower than a standard reference drug. Studies confirmed the hybrids tear the cell membrane, and the lead compound also raised stress chemistry inside the cells. The hybrids kept working after many rounds of exposure and showed low harm to human cells, hinting at a route to drugs that bacteria resist less easily.
Catalog record
| CREATOR | Elmira Gibadullina, Adel Shakirov, Margarita Neganova, Yulia Aleksandrova, Alexandra Voloshina, Anna Lyubina, Anastasiya Sapunova, Anna Strelnik, Kamil Ivshin, Assel Shuragaziyeva, Altynkul Toibazarova, Banu Diyarova, Anipa Tapalova, Nurbol Appazov, Alexander Burilov |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |