Genome-Wide DNA Methylation Profiling of Peripheral Blood Mononuclear Cells Reveals Epigenetic Signatures in Autism Spectrum Disorder
Thanit Saeliw, Wasana Yuwattana, Chayanit Poolcharoen, Marlieke Lisanne van Erp, Songphon Kanlayaprasit, Natchaya Vanwong, Valerie W. Hu, Pon Trairatvorakul, Weerasak Chonchaiya, Tewarit Sarachana · 2026
Read Genome-Wide DNA Methylation Profiling of Peripheral Blood Mononuclear Cells Reveals Epigenetic Signatures in Autism Spectrum Disorder by Thanit Saeliw, Wasana Yuwattana, Chayanit Poolcharoen, Marlieke Lisanne van Erp, Songphon Kanlayaprasit, Natchaya Vanwong, Valerie W. Hu, Pon Trairatvorakul, Weerasak Chonchaiya, Tewarit Sarachana (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13207186.txt.
Description
Autism arises from a mix of genes and environment, and chemical marks on DNA may carry part of that influence. Thanit Saeliw and co-authors scanned those marks across the genome in 2026, using blood cells from 100 children with autism and 50 children without it. They adjusted for age, sex, and the mix of cell types in each sample.
The team found over three and a half thousand DNA sites where the marks differed. The linked genes clustered in nerve signaling, synapse activity, and immune pathways. The sites also overlapped strongly with known autism risk genes. Overlap with brain tissue data was partial, so the authors call the blood marks candidate signs that need larger studies.
Catalog record
| CREATOR | Thanit Saeliw, Wasana Yuwattana, Chayanit Poolcharoen, Marlieke Lisanne van Erp, Songphon Kanlayaprasit, Natchaya Vanwong, Valerie W. Hu, Pon Trairatvorakul, Weerasak Chonchaiya, Tewarit Sarachana |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |