Soluble Dietary Fiber from Polygonatum cyrtonema Hua Attenuates Cyclophosphamide-Induced Intestinal Injury in Mice

Lingqiao Zeng, Shengxin Cui, Teng Peng · 2026

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Description

Lingqiao Zeng, Shengxin Cui, and Teng Peng test a plant fiber against gut injury from a chemotherapy drug in mice in a 2026 study. The drug cyclophosphamide can damage the intestine and weaken gut immunity. The fiber comes from the residue of a medicinal plant and is rich in soluble strands.

Sixty mice were split into control, drug-only, drug-plus-standard-aid, and three fiber dose groups. Fiber was fed for three weeks, with the drug given in the last days. Medium and high doses blunted weight loss and immune organ shrinkage, restored the gut lining's finger-like villi, and raised local defense proteins. Leak markers in blood fell. The authors present the fiber as a candidate functional food ingredient for gut health.

Catalog record

CREATORLingqiao Zeng, Shengxin Cui, Teng Peng
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE31 KB
VERSION1.0
LICENSECC BY 4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/articles/PMC13207160

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