Ergosterol: Biological Activities, Mechanistic Evidence, Pharmacokinetic Barriers, and Delivery Strategies
Mingkai Yao, Cui Li, Mengya Dang, Na Zhang, Xiaoyun Yang, Yuping Wang, Mengru Cai, Dong Bai · 2026
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Description
Ergosterol is a sterol found in fungi, best known as the raw material the body turns into vitamin D2. Mingkai Yao and co-authors review what is known about its effects on health. Reported actions include fighting tumors and inflammation and lowering cholesterol and uric acid.
The review pulls together work on the compound's chemistry, how fungi make it, and how the body handles it. The same traits that make it interesting also block its use: it barely dissolves in water, breaks down easily, and little of a swallowed dose reaches the blood. Studies link it to several signaling pathways, though direct proof of its targets is thin. The authors call for better delivery designs, careful dose studies, and human data before clinic use.
Catalog record
| CREATOR | Mingkai Yao, Cui Li, Mengya Dang, Na Zhang, Xiaoyun Yang, Yuping Wang, Mengru Cai, Dong Bai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 92 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |