SDK1 as an Independent Prognostic Biomarker in Primary Glioma: A Multi-Cohort Validation Study with Functional Characterization
Jun Hyun Lee · 2026
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Description
Jun Hyun Lee tests whether a cell-sticking protein called SDK1 can forecast outcomes for people with glioma, a brain tumor. He analyzed two large cohorts, one Chinese with 503 patients and one American with 572. Tumors with high SDK1 levels came with clearly worse survival in both groups, even after accounting for grade, mutations, and other markers. The link was strongest in the most aggressive tumors and absent in low-grade ones.
High-SDK1 tumors also showed more matrix-remodeling gene activity and more suppressive immune cells. The protein's signal stood apart from mutation burden. Lee presents SDK1 as a candidate warning marker that now needs lab validation.
Catalog record
| CREATOR | Jun Hyun Lee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |