IL-36-Driven Inflammation in Generalized Pustular Psoriasis: Immunological Insights from Plaque Psoriasis and Implications for Targeted Therapy
Klara Andrzejczak, Emilia Kucharczyk, Agata Sternak, Karol Biliński, Joanna Maj, Małgorzata Ponikowska · 2026
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Description
Klara Andrzejczak and co-authors review the IL-36 inflammation path in generalized pustular psoriasis and its lessons for therapy. This rare skin disease can threaten life in sudden flares. It is now seen as its own disease, not a plaque variant.
Faults in the IL-36 signaling axis drive the flares. Keratinocytes amplify inflammatory cascades through that axis. The response is innate and heavy in neutrophil cells. Sterile pustules form fast across skin and body. Plaque psoriasis leans instead on adaptive immune paths. Gene and transcript data back the sharp split. Mutations in IL-36 control genes appear in patients. Targeted drugs against this axis follow from the picture.
Catalog record
| CREATOR | Klara Andrzejczak, Emilia Kucharczyk, Agata Sternak, Karol Biliński, Joanna Maj, Małgorzata Ponikowska |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |