DNA Hypomethylation of MIR21 Drives Hsa-miR-21-5p Expression in High-Grade Meningiomas and Reshapes Transcriptomic Signatures of Oncogenic Pathways and Intercellular Communication
Paulina Kober, Szymon Baluszek, Beata Joanna Mossakowska, Izabella Myśliwy, Biniyam Tsegaye, Artur Oziębło, Tomasz Mandat, Mateusz Bujko · 2026
Read DNA Hypomethylation of MIR21 Drives Hsa-miR-21-5p Expression in High-Grade Meningiomas and Reshapes Transcriptomic Signatures of Oncogenic Pathways and Intercellular Communication by Paulina Kober, Szymon Baluszek, Beata Joanna Mossakowska, Izabella Myśliwy, Biniyam Tsegaye, Artur Oziębło, Tomasz Mandat, Mateusz Bujko (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13206978.txt.
Description
Paulina Kober and co-authors study a small RNA that runs high in aggressive meningiomas, the most common tumors inside the skull. Methyl marks on its gene, MIR21, thin out in the atypical and anaplastic grades, and the RNA, named miR-21-5p, rises with them. Their 2026 study traces what that RNA then does.
Gene activity scans found many predicted targets of the RNA among the genes that shift by tumor grade, mostly in cell signaling paths. Cell talk checks found grade linked shifts in the tumor's surroundings. One target pair, tied to interleukin 6 signals, fell in aggressive tumors. In lab cells, the RNA boosted growth and survival and tugged its targets down.
Catalog record
| CREATOR | Paulina Kober, Szymon Baluszek, Beata Joanna Mossakowska, Izabella Myśliwy, Biniyam Tsegaye, Artur Oziębło, Tomasz Mandat, Mateusz Bujko |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |