Modulation of mRNA Expression of Biomarkers in the UPR-PERK Pathway by Ellagic Acid in Metabolic Dysfunction-Associated Fatty Liver Disease
Stephane Pastrana-Cruz, Aarón Domínguez-López, Elizabeth Pérez-Hernández, Ángel Miliar-García, Norma Paniagua-Castro, Laura Adriana Ortiz-León, Antonio Ávila-Guerrero, Raúl J. Delgado-Macuil, Jorge Cornejo-Garrido, María Eugenia Jaramillo-Flores · 2026
Read Modulation of mRNA Expression of Biomarkers in the UPR-PERK Pathway by Ellagic Acid in Metabolic Dysfunction-Associated Fatty Liver Disease by Stephane Pastrana-Cruz, Aarón Domínguez-López, Elizabeth Pérez-Hernández, Ángel Miliar-García, Norma Paniagua-Castro, Laura Adriana Ortiz-León, Antonio Ávila-Guerrero, Raúl J. Delgado-Macuil, Jorge Cornejo-Garrido, María Eugenia Jaramillo-Flores (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13206915.txt.
Description
Stephane Pastrana-Cruz and co-authors test ellagic acid on stress pathway markers in fatty liver disease. The disease spans simple fat buildup to severe liver damage and cancer. A high-fat diet drives cell stress that feeds inflammation in the liver.
The team focused on the unfolded protein response and its PERK branch. That pathway switches on when the cell's protein workshop is strained. They measured messenger RNA levels for key markers in that pathway. Ellagic acid, a plant compound, was tested for shifting those levels. New approved drugs exist, but natural options still draw interest. The study adds gene-level data on one such option. It may help map safer ways to slow liver disease.
Catalog record
| CREATOR | Stephane Pastrana-Cruz, Aarón Domínguez-López, Elizabeth Pérez-Hernández, Ángel Miliar-García, Norma Paniagua-Castro, Laura Adriana Ortiz-León, Antonio Ávila-Guerrero, Raúl J. Delgado-Macuil, Jorge Cornejo-Garrido, María Eugenia Jaramillo-Flores |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |