Capture‐SELEX of DNA Aptamers for Highly Selective Binding of Folate
Yachen Xie, Yifan Chen, Juewen Liu · 2026
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Description
Yachen Xie and co-authors report a 2026 chemistry study on DNA strands that grab folate, the vitamin also known as B9. Folate matters most in pregnancy, and sensors that spot it fast and surely have clear medical value.
The team used a method called Capture-SELEX to fish out DNA aptamers, short strands that fold around a target. Their best strand bound folate tightly, with a dissociation constant of 640 nanomolar. Built into a glow-based sensor, it detected folate at very low levels, even in diluted blood serum. Look-alike molecules such as caffeine and adenine barely registered. The work gives food and health testers a sturdy new sensing part.
Catalog record
| CREATOR | Yachen Xie, Yifan Chen, Juewen Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |