Transglutaminase 2 at the Interface of Gene Regulation and Antigen Processing in HLA-Restricted Immunity of Celiac Disease
Faustina Barbara Cannea, Alessandra Padiglia · 2026
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Description
Faustina Cannea and Alessandra Padiglia review in 2026 the double life of an enzyme at the heart of celiac disease. The disease is an immune attack on the gut set off by gluten in people with the right genes. Those genes alone do not explain who falls ill or when.
The enzyme alters gluten pieces so they grip the immune system's display molecules more tightly, which wakes killer helper cells. It is also the main target of the body's misguided antibodies. Beyond that chemistry, the enzyme's own gene is switched by signals such as inflammation messengers. The review joins those threads: how the gene is run, and how its product readies gluten for display. That joint view may expose new points where the disease could be blocked.
Catalog record
| CREATOR | Faustina Barbara Cannea, Alessandra Padiglia |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |