Possible Involvement of Differential Ubiquitination as a Molecular Basis of Phenotypic Heterogeneity in Neurodevelopmental Disorders
Tadashi Nakagawa, Makiko Nakagawa · 2026
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Description
Tadashi Nakagawa and Makiko Nakagawa propose an explanation for why the same gene fault can leave one child's development nearly untouched and another's severely impaired, in a review published in 2026. Brain development disorders are famous for this spread of outcomes, and gene catalogs alone do not explain it. The authors turn to ubiquitin, the cell's tag for managing proteins.
Tagging is not a single switch but a layered system: which sites are free, which taggers are active, which removers oppose them, and which prior marks prime the protein. Those layers can differ by person, cell type, age, and setting, yielding a personal tagging landscape. The review argues that such differences translate gene variation into varied outcomes. Grasping that interplay could guide future treatments.
Catalog record
| CREATOR | Tadashi Nakagawa, Makiko Nakagawa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |