Sex-Specific Epigenetic Patterns in Endocannabinoid System Genes Following High-Altitude Exposure: An Exploratory Study
Carlotta Marrangone, Alessio Mosca, Manuel Marzola, Francesca Martella, Martina Di Bartolomeo, Vittore Verratti, Giovanni Martinotti, Claudio D’Addario · 2026
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Description
Carlotta Marrangone and seven co-authors track how high altitude rewrites chemical marks on stress-related genes, in a 2026 exploratory study. Twenty-one healthy lowlanders trekked in the Himalayas from 2,860 meters to 5,050 meters. The team collected mood questionnaires and saliva samples before the climb and again at altitude.
They measured methylation, a silencing mark, on two genes of the endocannabinoid system, the body's own cannabis-like signaling network that helps manage stress. In men, one spot on the first gene gained methylation at altitude, while women's marks stayed largely stable. Small RNA signals moved in both directions, differing by group. Mood dipped mildly with no clinical symptoms. The authors stress the small-RNA data are descriptive only. The sex-specific patterns, they suggest, hint that men and women regulate stress chemistry differently under thin air.
Catalog record
| CREATOR | Carlotta Marrangone, Alessio Mosca, Manuel Marzola, Francesca Martella, Martina Di Bartolomeo, Vittore Verratti, Giovanni Martinotti, Claudio D’Addario |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |