TOP2 and NOS2 Orchestrate the Generation of DNA Breaks to Promote Colitis Cancer Initiation
Ting-Kang Chang, Shiu-Ling Li, Anne-Cécile Brunac, Jia-Jun Huang, Yen-Hsiu Yeh, Pierre Brousset, Jean-Marc Egly, Tsai-Kun Li · 2026
Read TOP2 and NOS2 Orchestrate the Generation of DNA Breaks to Promote Colitis Cancer Initiation by Ting-Kang Chang, Shiu-Ling Li, Anne-Cécile Brunac, Jia-Jun Huang, Yen-Hsiu Yeh, Pierre Brousset, Jean-Marc Egly, Tsai-Kun Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13205054.txt.
Description
Ting-Kang Chang and co-authors study how DNA breaks build up at the start of colon cancer tied to gut inflammation, in work from 2026. People with long gut inflammation face higher colon cancer risk. Two factors stand out in the team work: an enzyme that twists DNA and an enzyme that makes a reactive gas.
In mouse models of gut inflammation and cancer, and in tissue from Crohn's patients, break markers rose along with both factors. Blocking either factor, by gene removal or by drugs, cut breaks and eased disease. Mice with one factor blocked also grew fewer tumors. Breaks clustered in the far colon, matching human cancer patterns. The authors name the pair as a joint drug target.
Catalog record
| CREATOR | Ting-Kang Chang, Shiu-Ling Li, Anne-Cécile Brunac, Jia-Jun Huang, Yen-Hsiu Yeh, Pierre Brousset, Jean-Marc Egly, Tsai-Kun Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |