Elevated Allele Frequency of a Common Germline LAG3 Variant Associated with Anemia, Thrombocytopenia and Peripheral Blast Percentage in Acute Myeloid Leukemia
Katja Seipel, Inna Shaforostova, Elisa Tarozzi, Marie-Noelle Kronig, Ulrike Bacher, Thomas Pabst · 2026
Read Elevated Allele Frequency of a Common Germline LAG3 Variant Associated with Anemia, Thrombocytopenia and Peripheral Blast Percentage in Acute Myeloid Leukemia by Katja Seipel, Inna Shaforostova, Elisa Tarozzi, Marie-Noelle Kronig, Ulrike Bacher, Thomas Pabst (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13205025.txt.
Description
Katja Seipel and five co-authors link a common inherited variant in an immune gene to leukemia features in this 2026 paper. The gene, LAG3, helps brake T cells. The team genotyped patients with acute myeloid leukemia who qualified for stem cell transplant, alongside a second checkpoint gene.
The LAG3 variant appeared far more often in patients than in the general European population, and more copies meant higher disease risk in dose fashion. Blood profiles differed by genotype: anemia, low platelets, and blast share varied with the variant. The second gene's variant showed no such links. The authors suggest the inherited variant shapes both susceptibility and disease character. They frame it as a candidate marker for further study.
Catalog record
| CREATOR | Katja Seipel, Inna Shaforostova, Elisa Tarozzi, Marie-Noelle Kronig, Ulrike Bacher, Thomas Pabst |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 19 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |