Circulating Tumor DNA in Upper Tract Urothelial Carcinoma: A Framework for Precision Perioperative Management
Amulya Prakash, Adriani Cherico, Adanma Ayanambakkam, Hyma Vani Polimera · 2026
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Description
Prakash and three co-authors wrote a 2026 review of blood tests for tumor DNA in upper tract urothelial carcinoma. The disease is a rare cancer of the kidney drainage system. Surgery often understages it, and hidden disease can return afterward. Tumor DNA fragments in blood could reveal leftover disease that scans miss. The review sorts the evidence for each proposed use and grades its strength.
The firmest evidence ties the blood marker to prognosis: positive results track with higher recurrence risk. Using it to pick drugs or set scan schedules is still unproven. Bladder cancer trials give supporting logic but cannot be copied directly. The authors lay out a research framework covering test choice, timing, and false results, and call for trials in this cancer specifically.
Catalog record
| CREATOR | Amulya Prakash, Adriani Cherico, Adanma Ayanambakkam, Hyma Vani Polimera |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |