Integrative Analysis of Major Depressive Disorder and Ovarian Cancer: From Genetic Association to Single-Cell Mechanisms
Chen Liu, Xueling Wang, Jiaqi Lu · 2026
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Description
Chen Liu, Xueling Wang, and Jiaqi Lu probe links between severe depression and ovarian cancer, in work from 2026. Prior work hints that depression raises the risk of this cancer and worsens survival. The paths in the body that join the two were not clear.
The team compared single-cell gene activity in blood from patients with each illness. One T cell group grew in both, so they studied it in depth. A gene in those cells, CLSTN3, tied to cancer risk through gene-based tests, and a shared gene switch was confirmed. Silencing that gene in cancer cells in the lab slowed their growth. The authors call the gene a lead worth more study, not a settled cause.
Catalog record
| CREATOR | Chen Liu, Xueling Wang, Jiaqi Lu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |