Mitofilin Preservation Mitigates Cardiac Injury in Donation-After-Circulatory-Death Hearts
Qun Chen, Zachary Kiernan, Gina Labate, Oluwatoyin Akande, Edward J. Lesnefsky, Mohammed Quader · 2026
Read Mitofilin Preservation Mitigates Cardiac Injury in Donation-After-Circulatory-Death Hearts by Qun Chen, Zachary Kiernan, Gina Labate, Oluwatoyin Akande, Edward J. Lesnefsky, Mohammed Quader (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13204712.txt.
Description
Qun Chen and co-authors show that guarding a pore-shaping protein spares donor hearts stopped by circulation death, in rat tests from two thousand twenty-six. Such hearts face a set burst of flow-loss harm, and a pore in the power units drives much of it. Cutting enzymes switch on in these hearts and chew the guard protein.
Bench tests proved one cutter directly breaks the protein down. Hearts given a cutter blocker kept the protein, opened the pore less, and showed smaller dead zones. The team frames timely cutter blocking as a route to stronger donor hearts. Readers in transplant science get a target with a clear chain of proof.
Catalog record
| CREATOR | Qun Chen, Zachary Kiernan, Gina Labate, Oluwatoyin Akande, Edward J. Lesnefsky, Mohammed Quader |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |