Upregulation of GnT-IVa and Its Critical Roles in ATRA-Induced Differentiation of Acute Promyelocytic Leukemia Cells
Siming Zhang, Tomoya Isaji, Meng Zheng, Yue Wang, Tiangui Wu, Tsukushi Saito, Yuhang Zhou, Tomohiko Fukuda, Shinichiro Takahashi, Jianguo Gu · 2026
Read Upregulation of GnT-IVa and Its Critical Roles in ATRA-Induced Differentiation of Acute Promyelocytic Leukemia Cells by Siming Zhang, Tomoya Isaji, Meng Zheng, Yue Wang, Tiangui Wu, Tsukushi Saito, Yuhang Zhou, Tomohiko Fukuda, Shinichiro Takahashi, Jianguo Gu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13204627.txt.
Description
A sugar-tagging enzyme helps leukemia cells mature under a vitamin-based drug, and a 2026 study by Siming Zhang pins down its role. The research article studies GnT-IVa, an enzyme that branches N-glycans, during all-trans retinoic acid treatment of acute promyelocytic leukemia cell models.
Enzyme levels and its branched glycan product rose sharply as NB4 and HL-60 cells differentiated under treatment. Deleting the enzyme's gene, but not its sibling gene, blocked differentiation and destabilized the surface marker CD11b that carries those branches. Public patient data showed low expression in this leukemia and better survival with higher expression in related cohorts, supporting differentiation therapy ideas.
Catalog record
| CREATOR | Siming Zhang, Tomoya Isaji, Meng Zheng, Yue Wang, Tiangui Wu, Tsukushi Saito, Yuhang Zhou, Tomohiko Fukuda, Shinichiro Takahashi, Jianguo Gu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |