Germline and Embryonic Mechanisms in the Epigenetic Inheritance of Neurodevelopmental and Cognitive Traits in Mammals

Mehmet Kizilaslan, Zeynep Kizilaslan, Hasan Khatib · 2026

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Description

Mehmet Kizilaslan, Zeynep Kizilaslan, and Hasan Khatib reviewed in 2026 how chemical marks on DNA in sperm, eggs, and early embryos can carry environmental effects into a child's brain development. Pollution, drugs, stress, and diet are the exposures in view. The puzzle spans fields that rarely talk to each other.

Marks laid down in the germline can survive fertilization, skew how the embryo parcels out its first cell types, and end by rewiring the growing nervous system. Some effects echo into later generations. The reviewers stitch four literatures into one chain of mechanism, from gamete to embryo to cognition. They argue only a systems view can predict which exposures matter and when they strike.

Catalog record

CREATORMehmet Kizilaslan, Zeynep Kizilaslan, Hasan Khatib
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE57 KB
VERSION1.0
LICENSECC BY 4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/articles/PMC13204612

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