Parasitic Infections as Reversible Hyper-IgE Phenocopies in Children with Markedly Elevated IgE: A Retrospective Cohort Study
Kazım Okan Dolu, İdan Fırat Unay, Yasemin Tepe, Hande Üçler Çınar, Çağla Karavaizoğlu, Himmet Haluk Akar · 2026
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Description
Kazım Dolu and co-authors ask whether parasitic infections can mimic a rare immune syndrome in children with markedly elevated IgE. IgE is an antibody that soars in allergy and in one inherited hyper-IgE syndrome. The team looked back at 127 children with IgE at or above a high threshold, each followed for a year or more at one tertiary allergy clinic from 2019 to 2024.
About a quarter of the children had parasitic infections: intestinal parasites, scabies mites, or hydatid cysts. Their IgE fell by about 64 percent over time, against about 27 percent in the non-parasitic group. Parasitic infection also made a return to below the high threshold far more likely. All syndrome score measures eased more in the parasite group. No child reached the score that would confirm the true syndrome. Stool checks earn a place in such work-ups, the team says.
Catalog record
| CREATOR | Kazım Okan Dolu, İdan Fırat Unay, Yasemin Tepe, Hande Üçler Çınar, Çağla Karavaizoğlu, Himmet Haluk Akar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |