RNA-Loaded Nanoparticles for Targeted Lung Delivery
Mark John Siringan, Xiaoyang Chen, Jiawei Huo · 2026
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Description
Mark Siringan, Xiaoyang Chen, and Jiawei Huo review how tiny particles might carry RNA medicines into the lungs, in a 2026 paper. The lung offers a huge surface and can be reached by breathing in a mist, which avoids needles. Yet mucus, surface fluids, constant clearing, and immune watch all block RNA from reaching lung cells. The spraying process itself can also damage the fragile cargo.
Particles built at nanometer scale can shield RNA, slip through mucus, and help cells take it in. The review covers the main RNA types, from silencing RNAs to messenger RNA and gene-editing systems, and the particle designs used for each. It weighs what works so far and what still blocks a practical inhaled RNA therapy.
Catalog record
| CREATOR | Mark John Siringan, Xiaoyang Chen, Jiawei Huo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |