Malic Enzyme 2 Regulates Dynamin-Related Protein 1-Dependent Mitochondrial Fission and Mitochondria-Associated Membranes to Drive Odontogenic Differentiation: An In Vitro and In Vivo Study
Jingzhou Li, Qianyi Shi, Xinyue Sheng, Haozhen Ma, Qianyi Deng, Yifan He, Fuping Zhang, Fang Huang · 2026
Read Malic Enzyme 2 Regulates Dynamin-Related Protein 1-Dependent Mitochondrial Fission and Mitochondria-Associated Membranes to Drive Odontogenic Differentiation: An In Vitro and In Vivo Study by Jingzhou Li, Qianyi Shi, Xinyue Sheng, Haozhen Ma, Qianyi Deng, Yifan He, Fuping Zhang, Fang Huang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13204223.txt.
Description
Jingzhou Li and seven co-authors published a dental cell biology study in twenty twenty-six on the power plants inside cells that build teeth. Dental papilla cells must become odontoblasts, the dentin makers, and the role of mitochondrial reshaping in that change was unclear. Microscopy and gene manipulation traced the sequence.
When differentiation was triggered, mitochondria fragmented early and their contact sites with the endoplasmic reticulum multiplied. A fission protein drove both changes, and an enzyme called malic enzyme 2 recruited it and kept the contact sites organized. Breaking any link in that chain stalled dentin formation in dishes and in animals. The authors name the axis a metabolic switch and a target for regenerating the dentin-pulp complex.
Catalog record
| CREATOR | Jingzhou Li, Qianyi Shi, Xinyue Sheng, Haozhen Ma, Qianyi Deng, Yifan He, Fuping Zhang, Fang Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |