Limonoid 7-Deacetoxy-7-oxogedunin (CG-1) Attenuates RANKL-Induced Osteoclastogenesis via Inhibiting PI3K/Akt-NFATc1 Axis
Atsushi Koike, Ko Fujimori · 2026
Read Limonoid 7-Deacetoxy-7-oxogedunin (CG-1) Attenuates RANKL-Induced Osteoclastogenesis via Inhibiting PI3K/Akt-NFATc1 Axis by Atsushi Koike, Ko Fujimori (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13204205.txt.
Description
Atsushi Koike and Ko Fujimori published this bone study in 2026. Osteoclasts are the cells that eat bone, and when they overwork, bone thins in diseases like osteoporosis. The pair tested a plant compound called CG-1, drawn from the seeds of a tropical tree. They asked if it could slow the making of osteoclasts from raw cells driven by a signal named RANKL.
CG-1 cut the count of mature bone-eating cells and muted the genes that build them. Dosing only in the first three days worked as well as dosing all five, so the early stage is key. The compound damped a growth path inside the cells and lowered the master switch gene for the change. The authors say CG-1 could seed drugs that curb bone loss, though animal tests come next.
Catalog record
| CREATOR | Atsushi Koike, Ko Fujimori |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |