Ganoderic Acid A Attenuates Pathological Cardiac Hypertrophy by Attenuating Inflammatory Responses
Changlin Zhen, Yonghui Zhang, Hui Tan, Dan Liu, Xiuzhen He, Wansong Chen · 2026
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Description
A heart squeezed by high pressure thickens its walls, and that thickening paves the road to failure. Changlin Zhen and co-authors test a mushroom compound against the process in a 2026 study. The compound, the main active ingredient of a prized fungus, had already shown heart protection in other rat work.
In mice with a narrowed aorta, the compound eased the thickening; in dishes, it calmed hormone-driven growth of heart cells. It turned down the genes of thickening and scarring and quieted inflammation, likely through a known signaling switch. The team offers the compound as a candidate for future treatment of the thickened heart.
Catalog record
| CREATOR | Changlin Zhen, Yonghui Zhang, Hui Tan, Dan Liu, Xiuzhen He, Wansong Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |