Mitochondria-Associated mRNAs Restore ATP During Oxidative Stress via Cytosolic Translation
Dong-Bin Back, Gen Hamanaka, Ji-Hyun Park, Shin Ishikane, Masayoshi Tanaka, Takafumi Nakano, Yoshihiko Nakamura, Kazuhide Hayakawa · 2026
Read Mitochondria-Associated mRNAs Restore ATP During Oxidative Stress via Cytosolic Translation by Dong-Bin Back, Gen Hamanaka, Ji-Hyun Park, Shin Ishikane, Masayoshi Tanaka, Takafumi Nakano, Yoshihiko Nakamura, Kazuhide Hayakawa (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13203415.txt.
Description
Dong-Bin Back and seven co-authors find that RNA packages from mitochondria can restore cell energy after oxidative injury. Their study was published in twenty twenty-six. Transplanting mitochondria is an idea for reviving cells hurt by oxygen stress, but how energy returns was murky.
Plain placental mitochondria lifted energy slightly in healthy cells yet failed after peroxide injury. Lipid-coated mitochondria, and coated packages of mitochondria-linked RNAs alone, restored energy strongly in hurt cells. Gene reads showed the energy return did not come from fixing the usual energy gene programs. The RNA packages worked without changing the host's gene activity at all. Bare mitochondria instead stirred broad stress and immune gene responses. The result hints that the cargo, not the organelle, does much of the work.
Catalog record
| CREATOR | Dong-Bin Back, Gen Hamanaka, Ji-Hyun Park, Shin Ishikane, Masayoshi Tanaka, Takafumi Nakano, Yoshihiko Nakamura, Kazuhide Hayakawa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |