Integrated Omics Analysis of the Effects of Nano-Antimicrobial Peptide on the Intestinal Microbiota and Metabolome of Tibetan Sheep
Yaqin Zhao, Xiaoshan Wang, Haixia Jing, Liyuan Zhao, Fengjun Liu · 2026
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Description
Yaqin Zhao and co-authors published this animal science study in 2026. It tests what nano-sized antimicrobial peptides, a feed additive meant to fight gut microbes more gently than antibiotics, do to Tibetan sheep. The team compared sheep on a normal diet with sheep given the additive. They sampled three gut sites, the rumen, small intestine, and rectum, and profiled both the microbes and the small molecules present.
The additive's effects were site-specific. The small intestine's microbial community shifted clearly, while the rumen and rectal communities stayed fairly stable. Metabolic profiles moved too, above all in bile acid, fatty acid, and membrane lipid pathways. Statistical links tied certain microbe groups to certain metabolites in a steady pattern. The authors suggest the additive helps maintain energy balance and gut stability by tuning the small intestine's ecology.
Catalog record
| CREATOR | Yaqin Zhao, Xiaoshan Wang, Haixia Jing, Liyuan Zhao, Fengjun Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |