Arecoline-induced EV-mediated ZNF582 hypermethylation drives IFIT1–PD-L1 immune evasion in oral squamous cell carcinoma
Hui-Hsin Ko, Hsin-Hui Peng, Chun-Pin Chiang, Hsiang-Fong Kao, Hung-Ying Lin, Mark Yen-Ping Kuo, Shih-Jung Cheng · 2026
Read Arecoline-induced EV-mediated ZNF582 hypermethylation drives IFIT1–PD-L1 immune evasion in oral squamous cell carcinoma by Hui-Hsin Ko, Hsin-Hui Peng, Chun-Pin Chiang, Hsiang-Fong Kao, Hung-Ying Lin, Mark Yen-Ping Kuo, Shih-Jung Cheng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13202916.txt.
Description
Betel nut chewing can reprogram mouth cancer cells through tiny vesicles, and a 2026 study by Hui-Hsin Ko traces that pathway. The research article examines how arecoline, the active agent in areca nut, drives methylation of the ZNF582 gene in oral squamous cell carcinoma through extracellular vesicles.
Working with two cancer cell lines, the team isolated vesicles and measured gene methylation, protein levels, and immune cell behavior. Silencing ZNF582 made cancer cells grow, migrate, and resist immune attack more strongly, partly by raising the PD-L1 shield protein through an interferon-related route. The authors propose blocking this vesicle pathway as a treatment strategy for exposed patients.
Catalog record
| CREATOR | Hui-Hsin Ko, Hsin-Hui Peng, Chun-Pin Chiang, Hsiang-Fong Kao, Hung-Ying Lin, Mark Yen-Ping Kuo, Shih-Jung Cheng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |