Microbiome-innate immune crosstalk in acute exacerbation of idiopathic pulmonary fibrosis: an amplification framework
Wanwan Zhang, Jiayang Yi, Zhi Li · 2026
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Description
Wanwan Zhang, Jiayang Yi, and Zhi Li propose a framework in 2026 for sudden worsening in a scarring lung disease. These flare-ups kill many patients with idiopathic pulmonary fibrosis, and their drivers are unclear. The review gathers evidence that lung microbes and innate immunity amplify each other. Microbial imbalance plus danger signals from hurt tissue may overfire pattern sensors and reshape immune cells.
Harmful neutrophil traps and a scar-linked macrophage program enter the picture. Antibiotics and biofilm traits may keep microbes from clearing, feeding the loop. Direct proof inside flare-ups is still thin, the authors admit. They frame testable ideas for sorting patients and guiding treatment.
Catalog record
| CREATOR | Wanwan Zhang, Jiayang Yi, Zhi Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |