Combination of APS, HMGN1, and anti-TNFR2 antibody remodels the tumor immune microenvironment to enhance antitumor immunity in colorectal cancer
Liming Zhao, Xia Pei, Haobo Wu, Shengwen Zhou, Jia Song, Quan Wan, Hang Lv, Jing Xu, Yingjie Nie · 2026
Read Combination of APS, HMGN1, and anti-TNFR2 antibody remodels the tumor immune microenvironment to enhance antitumor immunity in colorectal cancer by Liming Zhao, Xia Pei, Haobo Wu, Shengwen Zhou, Jia Song, Quan Wan, Hang Lv, Jing Xu, Yingjie Nie (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13202584.txt.
Description
Liming Zhao and co-authors combine three agents to wake the immune system against bowel cancer. Their 2026 study uses a mouse model of colorectal cancer. One agent is a plant sugar from astragalus root, one wakes up the cells that present targets, and one frees killer T cells from their brakes.
The triple mix wiped out the tumours and left lasting, tumour-specific memory. Target-presenting cells switched on, killer T cells flooded the tumour, and brake cells fell away. Signs of T cell wear-out dropped as well. The authors argue the three parts help each other: better target display, less suppression, and restored T cell work against the tumour over time.
Catalog record
| CREATOR | Liming Zhao, Xia Pei, Haobo Wu, Shengwen Zhou, Jia Song, Quan Wan, Hang Lv, Jing Xu, Yingjie Nie |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |