Synthesis and biological evaluation of new brassinosteroid analogs with C-22 benzoate function
María Núñez, Camila Escobar, Mario Párraga, Mauricio Soto, Luis Espinoza-Catalán, Katy Díaz, Andrés F Olea · 2026
Read Synthesis and biological evaluation of new brassinosteroid analogs with C-22 benzoate function by María Núñez, Camila Escobar, Mario Párraga, Mauricio Soto, Luis Espinoza-Catalán, Katy Díaz, Andrés F Olea (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13202480.txt.
Description
María Núñez and six colleagues made new analogs of brassinosteroids, the plant hormones that steer growth. The new compounds carry a benzoate group at a key carbon, decorated with added groups of differing size and electronegativity. Activity was tested two ways: bending of rice leaf segments, a classic hormone assay, and root growth inhibition in Arabidopsis. Buildup of a signaling protein measured pathway activation inside cells.
Set against earlier series, the tests isolated the effect of one ring's chemistry. A two-hydroxy setup beat carbonyl or single-hydroxy variants. Docking math linked binding strength to the measured responses. The team could thus follow structure from first binding, through a signaling step, to whole plant response. Such maps help design growth regulators that work at lower doses in agriculture.
Catalog record
| CREATOR | María Núñez, Camila Escobar, Mario Párraga, Mauricio Soto, Luis Espinoza-Catalán, Katy Díaz, Andrés F Olea |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |