Nrf2/GPX4‐Dependent Ferroptosis Inhibition: The Central Mechanism Underpinning Germacrone‐Induced Cardioprotection in Myocardial Infarction
Jiaxiang Liao, Zitian Wang, Zhou Huang, Jincheng Li, Jie Yang, Chunyun Fang, Dongling Huang, Fan Wang, Xueling Lu, Yiling Zhai, Wei Wang, Anjali Chauhan · 2026
Read Nrf2/GPX4‐Dependent Ferroptosis Inhibition: The Central Mechanism Underpinning Germacrone‐Induced Cardioprotection in Myocardial Infarction by Jiaxiang Liao, Zitian Wang, Zhou Huang, Jincheng Li, Jie Yang, Chunyun Fang, Dongling Huang, Fan Wang, Xueling Lu, Yiling Zhai, Wei Wang, Anjali Chauhan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13202446.txt.
Description
A plant compound from turmeric relatives protects heart muscle in a 2026 study by Jiaxiang Liao, focused on a form of cell death called ferroptosis. The research article tests germacrone in mice with drug-induced heart attacks and in injured heart cells grown in the laboratory.
Germacrone given daily for a week reduced heart injury, improved cardiac function, and limited tissue damage in the mouse model. It also blocked ferroptosis by raising protective proteins along the Nrf2 and GPX4 pathway in treated tissue. When the team added an Nrf2 blocker, the protection disappeared, confirming the pathway's central role and nominating it as a treatment target.
Catalog record
| CREATOR | Jiaxiang Liao, Zitian Wang, Zhou Huang, Jincheng Li, Jie Yang, Chunyun Fang, Dongling Huang, Fan Wang, Xueling Lu, Yiling Zhai, Wei Wang, Anjali Chauhan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |