Real-world damage accrual in Sjögren’s disease: a 5-year multicentre GIRRCS cohort analysis
Onorina Berardicurti, Annalisa Marino, Luca Navarini, Andrea Pilato, Marta Vomero, Letizia Pia Di Corcia, Irene Genovali, Damiano Currado, Lidia La Barbera, Rosaria Irace, Paola Conigliaro, Victoriya Pavlych, Valeria Guardo, Giorgio Carlino, Sara Ferrigno, Rosa Daniela Grembiale, Annamaria Iagnocco, · 2026
Read Real-world damage accrual in Sjögren’s disease: a 5-year multicentre GIRRCS cohort analysis by Onorina Berardicurti, Annalisa Marino, Luca Navarini, Andrea Pilato, Marta Vomero, Letizia Pia Di Corcia, Irene Genovali, Damiano Currado, Lidia La Barbera, Rosaria Irace, Paola Conigliaro, Victoriya Pavlych, Valeria Guardo, Giorgio Carlino, Sara Ferrigno, Rosa Daniela Grembiale, Annamaria Iagnocco, (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13202125.txt.
Description
Permanent organ damage accumulates quietly in Sjögren's disease, and a 2026 cohort analysis authored by Onorina Berardicurti charts that accrual over five years. The research article follows 429 adults in an Italian multicentre research network, measuring irreversible damage across eye, mouth, and systemic domains with a validated damage index.
Nearly half the patients already had some damage at baseline, and the share rose to about two thirds after five years of follow-up. Higher baseline disease activity predicted damage in every domain, while an abnormal tear test specifically forecast eye damage. Antibodies, inflammation markers, and repeated mouth infections added domain-specific risks, pointing to earlier monitoring for high-risk patients.
Catalog record
| CREATOR | Onorina Berardicurti, Annalisa Marino, Luca Navarini, Andrea Pilato, Marta Vomero, Letizia Pia Di Corcia, Irene Genovali, Damiano Currado, Lidia La Barbera, Rosaria Irace, Paola Conigliaro, Victoriya Pavlych, Valeria Guardo, Giorgio Carlino, Sara Ferrigno, Rosa Daniela Grembiale, Annamaria Iagnocco, |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |