Systemic inflammation mediates the link between cardiometabolic multimorbidity and cognitive function among older U.S. adults: evidence from NHANES
Zhiyuan Wang, Xuejie Hu, Yongbin Wang, Jinping Sun · 2026
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Description
Zhiyuan Wang and co-authors test whether body-wide inflammation explains part of the link between multiple cardiometabolic diseases and weaker thinking in older adults. Their 2026 study uses a national United States health survey covering nearly twenty-five hundred adults aged sixty and older. Thinking was measured with three standard tests, and blood markers were combined into one inflammation score.
Adults carrying several heart and metabolic conditions scored notably worse on a symbol substitution test. Higher inflammation tracked with both the disease burden and the poorer scores. Statistical mediation analysis suggested inflammation carries part of the effect from disease to cognition. The links were not simple straight lines. The authors argue that calming inflammation might protect the aging brain, a claim that now needs direct testing.
Catalog record
| CREATOR | Zhiyuan Wang, Xuejie Hu, Yongbin Wang, Jinping Sun |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |