The acyl- and alkyl-glycerone phosphate reductase DHRS7 is involved in the production of distinct plasmalogen species from DHRS7B
Tenga Takahashi, Kento Otsuka, Takayuki Sassa, Akio Kihara · 2026
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Description
Plasmalogens are special fats in cell membranes, and cells build them through a chain of enzymes. One enzyme in the chain, DHRS7B, was known to perform a key reduction step. Four authors asked whether its close relative DHRS7 does the same job, making matched cell lines missing one enzyme, the other, or both, and measuring the products.
Both enzymes proved to do the job, but on different menus: DHRS7 favored certain fatty acid chains, strongest for one called C18:1, while DHRS7B covered every species tested. The two also live in different cell compartments, one in the endoplasmic reticulum and the other in peroxisomes. In test tubes, DHRS7 showed the same double activity as its relative. The authors conclude that DHRS7 is a previously unrecognized player in making these membrane fats, with its own distinct profile.
Catalog record
| CREATOR | Tenga Takahashi, Kento Otsuka, Takayuki Sassa, Akio Kihara |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |