Heterologous expression of hydroxylase coupled with pathway optimization enables highly efficient ʟ-DOPA production in Corynebacterium glutamicum
Mengzhen Jia, Ran Duan, Yan Jiang, Xiaohe Chu, Xiaoyu Wu, Hui Yang, Bangce Ye, Bin Zhang · 2026
Read Heterologous expression of hydroxylase coupled with pathway optimization enables highly efficient ʟ-DOPA production in Corynebacterium glutamicum by Mengzhen Jia, Ran Duan, Yan Jiang, Xiaohe Chu, Xiaoyu Wu, Hui Yang, Bangce Ye, Bin Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13199934.txt.
Description
Mengzhen Jia and co-authors engineered a bacterium to brew a key Parkinson's drug ingredient, in a 2026 study. The compound, L-DOPA, is the direct forerunner of dopamine and a mainstay drug for the disease. Their host was a workhorse microbe used in food and chemical plants. They first checked it could bear the product, then built the making pathway step by step.
Two added enzymes opened the path, while cuts to rival branches kept the flow aimed at the target. Tuning the gene switches raised the supply of the starting material. The final strain reached about 711 milligrams per liter in flask tests. The team then scaled the run up.
Catalog record
| CREATOR | Mengzhen Jia, Ran Duan, Yan Jiang, Xiaohe Chu, Xiaoyu Wu, Hui Yang, Bangce Ye, Bin Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |