Avian coronaviruses induce inflammatory responses by activating p38/MAPK signaling and NLRP3/caspase-1 inflammasomes through sphingosine-1-phosphate receptor 1
Hongtao Xiao, Siyao Yu, Shijing Li, Zhifei Xu, Jiayang Chen, Lijin Lai, Qiuyan Lin, Tao Ren, Libin Chen · 2026
Read Avian coronaviruses induce inflammatory responses by activating p38/MAPK signaling and NLRP3/caspase-1 inflammasomes through sphingosine-1-phosphate receptor 1 by Hongtao Xiao, Siyao Yu, Shijing Li, Zhifei Xu, Jiayang Chen, Lijin Lai, Qiuyan Lin, Tao Ren, Libin Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13198749.txt.
Description
Hongtao Xiao, Siyao Yu, and their co-authors traced how a bird coronavirus inflames the kidneys of chickens. Their 2026 study concerns infectious bronchitis virus, a major threat to poultry worldwide that often damages the kidneys. The team profiled the chemistry of infected kidney tissue from clean, germ free raised birds.
Infection reshaped the kidney's small molecule mix, lowering most amino acids as the virus drew on them to copy itself. One fat molecule, sphingosine-1-phosphate, rose sharply. Follow up experiments showed its receptor switches on two response systems: a MAPK pathway and a particle called the inflammasome that releases inflammatory signals. Blocking that receptor is suggested as a route to protect the kidneys.
Catalog record
| CREATOR | Hongtao Xiao, Siyao Yu, Shijing Li, Zhifei Xu, Jiayang Chen, Lijin Lai, Qiuyan Lin, Tao Ren, Libin Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |