TET1 downregulation in the dorsal root ganglion and spinal cord is required for short-term sleep disturbance to delay surgical pain recovery
Jing Cao, Po-Kai Wang, Bo Xu, Xiyao Gu, Zhiqiang Pan, Weihua Cai, Songxue Su, Zhixiao Li, Julia Delorenzo, Alex Bekker, Huijuan Hu, Yuan-Xiang Tao · 2026
Read TET1 downregulation in the dorsal root ganglion and spinal cord is required for short-term sleep disturbance to delay surgical pain recovery by Jing Cao, Po-Kai Wang, Bo Xu, Xiyao Gu, Zhiqiang Pan, Weihua Cai, Songxue Su, Zhixiao Li, Julia Delorenzo, Alex Bekker, Huijuan Hu, Yuan-Xiang Tao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13197928.txt.
Description
Jing Cao and co-authors study why poor sleep slows healing after surgery, in work published in 2026. They focus on a gene switch called TET1 in nerve tissue near the spine. When sleep is cut short, levels of that switch fall. The team asked whether that fall is part of why pain lasts longer.
In rats, the team gave a form of the gene back or blocked it in key nerve sites. They tracked pain acts, gene levels, and marks on a pain-related gene. Restoring the switch eased the delay, while blocking it made things worse. The work points to one clear path that links lost sleep to slow pain relief.
Catalog record
| CREATOR | Jing Cao, Po-Kai Wang, Bo Xu, Xiyao Gu, Zhiqiang Pan, Weihua Cai, Songxue Su, Zhixiao Li, Julia Delorenzo, Alex Bekker, Huijuan Hu, Yuan-Xiang Tao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |