The rheological properties of Candida albicans colony biofilms are impacted by matrix production and cell wall structure
Clémence Abriat, Linqi Huang, Sham Sunder, Joshua S Bauman, Grant A Landry, Hunter RLischwe Mueller, JScott VanEpps, Michael J Solomon, Anuj Kumar · 2026
Read The rheological properties of Candida albicans colony biofilms are impacted by matrix production and cell wall structure by Clémence Abriat, Linqi Huang, Sham Sunder, Joshua S Bauman, Grant A Landry, Hunter RLischwe Mueller, JScott VanEpps, Michael J Solomon, Anuj Kumar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13197771.txt.
Description
Clemence Abriat and co-authors measure how gene deletions stiffen or soften biofilms of the yeast Candida albicans, in work from twenty twenty-six. Biofilms act like soft living gels whose stiffness shapes infection outcomes. Bacterial film stiffness is well studied; fungal films are not. New rheology methods quantify colony biofilm mechanics here. Mutants lacking wall or matrix genes form the test panel.
Three single deletions raise elastic stiffness noticeably in films. Restoring each gene returns stiffness to normal levels. Those stiff mutants grow smoother films with fewer filaments. They also make less matrix and resist antifungal drug less. Gene profiles shift across wall, lipid, and filament programmes. Film mechanics emerge as a distinct, gene-driven trait. Antifungal strategy may one day target film stiffness itself.
Catalog record
| CREATOR | Clémence Abriat, Linqi Huang, Sham Sunder, Joshua S Bauman, Grant A Landry, Hunter RLischwe Mueller, JScott VanEpps, Michael J Solomon, Anuj Kumar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |