Characterization of the Second-Generation Covalent Fragment Library (CovLib Gen2): Thiol Reactivity Profiling and p53-Y220C Rescue
Martin Schwer, Sven R Aldea, Marc U Engelhardt, Jason Stahlecker, Janosch Rheinganz, Aaron Langkamp, Frank M Boeckler · 2026
Read Characterization of the Second-Generation Covalent Fragment Library (CovLib Gen2): Thiol Reactivity Profiling and p53-Y220C Rescue by Martin Schwer, Sven R Aldea, Marc U Engelhardt, Jason Stahlecker, Janosch Rheinganz, Aaron Langkamp, Frank M Boeckler (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13197676.txt.
Description
Martin Schwer and six co-authors present a 2026 study of a second generation library of small chemical fragments that bond permanently to proteins. Such fragments can reach pockets that normal drugs cannot, including flat or hidden sites. A well profiled library saves discovery teams months of screening.
The new library holds 81 fragments across five reactive classes, from epoxides to sulfur reactive rings. The team measured each fragment's physical traits and its speed of reaction with sulfur groups, a common anchor in proteins. One test case revived a broken tumor suppressor protein, p53, in its mutant form. The paper reports which fragments reacted cleanly and which were too hot.
Catalog record
| CREATOR | Martin Schwer, Sven R Aldea, Marc U Engelhardt, Jason Stahlecker, Janosch Rheinganz, Aaron Langkamp, Frank M Boeckler |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |