Multiomics Identification of Radioresistance‐Associated Biomarkers and Prognostic Model Construction in Rectal Cancer
Zongxueni Deng, Caiyan Lu, Zhenxin Wang, Lin Zhang · 2026
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Description
Zongxueni Deng and colleagues built a 2026 forecast model for rectal cancer response to radiation. Radiation is a main local treatment for rectal cancer, yet some tumors resist it and outcomes suffer. The team mined public gene datasets to find markers of that resistance.
They combined bulk gene data from close to one thousand patients with single-cell data from six samples. A risk score built from gene patterns linked to immune cell mix, drug sensitivity, and growth pathways. Five key genes stood out as tied to radiation response. Protein checks in databases and animal tissue backed the picks. The genes may serve as markers and drug targets, pending clinical tests.
Catalog record
| CREATOR | Zongxueni Deng, Caiyan Lu, Zhenxin Wang, Lin Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |