Characterization and evaluation of a novel polylactic acid-made bioreactor for large-scale adherent cell expansion
Björn Boshof, Alena Hüppner, Johanna Eichberg, Henning Reyer, Lukas Käßer, Anne Kölsch · 2026
Read Characterization and evaluation of a novel polylactic acid-made bioreactor for large-scale adherent cell expansion by Björn Boshof, Alena Hüppner, Johanna Eichberg, Henning Reyer, Lukas Käßer, Anne Kölsch (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13197453.txt.
Description
Björn Boshof and colleagues evaluate a new cell growth vessel called CellScrew in 2026. Growing surface-loving cells at large scale is key for making proteins, gene therapy vectors, and vaccines. Stacked flasks need much hand work and lack process control, so a rotating vessel could help.
The vessel turns its growth surface in a steady roll, which improves mixing and oxygen flow. The team tested three cell types, including human kidney cells used in production. Cell yields and survival matched stacked flasks. Pulling cells off the surface worked well and used far less release fluid. The authors see a scalable, lower-waste swap for classic flask stacks, pending wider tests.
Catalog record
| CREATOR | Björn Boshof, Alena Hüppner, Johanna Eichberg, Henning Reyer, Lukas Käßer, Anne Kölsch |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |