Myeloid/lymphoid neoplasm with FLT3 gene fusion: report of a case with a novel t(5;13)(q13;q12) SSBP2::FLT3 fusion
James R Cook, Caroline Astbury, David S Bosler, John C Molina, Heesun J Rogers, Ronald M Sobecks, Anna B Owczarczyk · 2026
Read Myeloid/lymphoid neoplasm with FLT3 gene fusion: report of a case with a novel t(5;13)(q13;q12) SSBP2::FLT3 fusion by James R Cook, Caroline Astbury, David S Bosler, John C Molina, Heesun J Rogers, Ronald M Sobecks, Anna B Owczarczyk (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13197295.txt.
Description
James Cook and co-authors report a blood cancer case with a brand-new gene fusion in a 2026 paper. Some mixed myeloid and lymphoid cancers hinge on fused tyrosine kinase genes. Finding the fusion can unlock targeted drugs. RNA sequencing is the net that catches them.
Their patient's scans showed widespread glowing lymph nodes. Sequencing exposed an SSBP2-FLT3 fusion from a chromosome swap never reported before. Adding the FLT3 blocker gilteritinib cleared the node disease where other care had not. A bone marrow transplant followed. Two years on, the patient stays in full remission. The case urges early fusion hunting in odd presentations of this cancer family.
Catalog record
| CREATOR | James R Cook, Caroline Astbury, David S Bosler, John C Molina, Heesun J Rogers, Ronald M Sobecks, Anna B Owczarczyk |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 11 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |