Tonic dopamine sensing reveals a D2 and D3-mediated dopamine response to raclopride in ClockΔ19 mice model
Bingchen Wu, Elisa Castagnola, Elaine Robbins, Mariya Kaminsky, Subramaniam Sanker, Colleen A McClung, Xinyan Tracy Cui · 2026
Read Tonic dopamine sensing reveals a D2 and D3-mediated dopamine response to raclopride in ClockΔ19 mice model by Bingchen Wu, Elisa Castagnola, Elaine Robbins, Mariya Kaminsky, Subramaniam Sanker, Colleen A McClung, Xinyan Tracy Cui (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13197223.txt.
Description
Bingchen Wu and co-authors study how a clock gene shapes dopamine signals in the mouse brain, in a research paper from 2026. Daily body rhythms affect mood and body health, and breaks in those rhythms link to brain disorders. The team used mice with a changed Clock gene, called ClockΔ19, and mice with the normal gene.
The team placed fine coated fibers in the brain area called the striatum to sense dopamine levels. Two drugs helped show how the system reacts: one blocks D2 and D3 receptors, and one blocks dopamine reuptake. The mutant mice showed a faster response to the blocking drug, which points to more sensitive receptors. Tests of gene activity also showed more of the enzyme that helps make dopamine, and more D2 and D3 receptors in key brain areas.
Catalog record
| CREATOR | Bingchen Wu, Elisa Castagnola, Elaine Robbins, Mariya Kaminsky, Subramaniam Sanker, Colleen A McClung, Xinyan Tracy Cui |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |