Effects of Remimazolam Dose and Bolus Injection Rate on Hiccups During Painless Colonoscopy: A Double-Blind Randomized Clinical Trial
Yanping Lu, Xuewei Wang, Henjing Zou, Changhui Shao, Guangyi Lai, Shan Ou · 2026
Read Effects of Remimazolam Dose and Bolus Injection Rate on Hiccups During Painless Colonoscopy: A Double-Blind Randomized Clinical Trial by Yanping Lu, Xuewei Wang, Henjing Zou, Changhui Shao, Guangyi Lai, Shan Ou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13196798.txt.
Description
Yanping Lu and five co-authors test how dose and injection speed affect hiccups during sedation for colonoscopy. The sedative remimazolam works fast and wears off fast, but hiccups during the procedure can jostle the scope. Their 2026 trial randomly assigned adults to one of four combinations in a two-by-two design.
Patients received either 0.3 or 0.4 milligrams per kilogram, pushed over 10 or 20 seconds, with neither patients nor assessors knowing the assignment. Both levers mattered on their own: the higher dose and the slower push each cut hiccup rates. Adjusted analysis confirmed the pattern, and no strong interaction appeared between the two. Secondary measures covered movement, extra doses, and recovery time. Slowing the push is a simple, free fix.
Catalog record
| CREATOR | Yanping Lu, Xuewei Wang, Henjing Zou, Changhui Shao, Guangyi Lai, Shan Ou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |