Endothelial soluble APP/APLP2 promote heart repair through KIT-mediated angiogenesis
Haruya Kawase, Shangmin Liu, Sabrina Kurz, Verena Bengelsdorff, Remy Bonnavion, Young-June Jin, Kenneth Anthony Roquid, Haaglim Cho, Guozheng Liang, Marija Banićević, Niharika Shiva, Paula Sofía Yunes-Leites, Stefan Günther, Lukas Tombor, Stefanie Dimmeler, Mario Looso, Kenny Mattonet, Nina Wettschu · 2026
Read Endothelial soluble APP/APLP2 promote heart repair through KIT-mediated angiogenesis by Haruya Kawase, Shangmin Liu, Sabrina Kurz, Verena Bengelsdorff, Remy Bonnavion, Young-June Jin, Kenneth Anthony Roquid, Haaglim Cho, Guozheng Liang, Marija Banićević, Niharika Shiva, Paula Sofía Yunes-Leites, Stefan Günther, Lukas Tombor, Stefanie Dimmeler, Mario Looso, Kenny Mattonet, Nina Wettschu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13196746.txt.
Description
Haruya Kawase and co-authors find a repair role for amyloid precursor protein in the heart in this 2026 paper. That protein is best known for amyloid-beta, a factor in Alzheimer disease. Its normal job outside the brain was largely unknown.
After a heart attack, low oxygen raised enzymes in vessel lining cells that clip the protein into a soluble form. Mice lacking the protein and its partner in those cells grew fewer new vessels. They also faced more heart failure and death after infarction. Restoring the soluble form rescued the repair. The fragment boosts a vessel growth receptor called KIT, which drives new vessel growth.
Catalog record
| CREATOR | Haruya Kawase, Shangmin Liu, Sabrina Kurz, Verena Bengelsdorff, Remy Bonnavion, Young-June Jin, Kenneth Anthony Roquid, Haaglim Cho, Guozheng Liang, Marija Banićević, Niharika Shiva, Paula Sofía Yunes-Leites, Stefan Günther, Lukas Tombor, Stefanie Dimmeler, Mario Looso, Kenny Mattonet, Nina Wettschu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |